Overview: progressive degeneration of the corpus callosum previous literature called Marchliafara-Bignami disease, concurrency is a rare disease in chronic alcoholism. Mostly middle-aged men, often with alcohol, malnutrition and other diseases coexist. disease mainly affects the middle layer of the corpus callosum, followed by the neighboring white matter and small brain, legs may also be involved. No specific treatment for poor prognosis.[Cause]
this disease and alcoholism are related, but the disease pathogenesis is unknown. Mainly affects the middle layer of the corpus callosum, followed by the neighboring white matter and small brain, legs may also be involved. Optic radiation and the anterior commissure involvement is rare. Symmetric demyelination lesions. Part or the entire corpus callosum involvement, involvement of the central most important part of the fiber. damage to soft gray area with the naked eye. Microscopic residual glial and vascular lesions and no significant relationship between blood vessels.
(B) the pathogenesis
Marchliafara-Bignami disease pathogenesis is unclear, long-term alcohol abuse is a significant risk factor is undoubtedly , has indeed confirmed that a large number of uncontrolled drinking, many organ systems of the body much harm to both the role of the nervous system is alcohol abuse a major target organ of disease. But the disease is also found in non-alcoholics. Experimental cyanide poisoning and carbon monoxide poisoning can cause the disease, it may be related to ischemia and hypoxia have a relationship.[Sign]
progressive degeneration of the corpus callosum, the early symptoms?
2.Marchliafara-Bignami disease no characteristic clinical manifestations, and other nervous system damage caused by alcoholism are similar, but many patients have cognitive and behavioral abnormalities. Usually anxiety, apathy, hallucinations, mood disorders and abnormal behavior. Patients can occur within a few years for dementia. Some of the performance of periodic stupor and coma, may occur tremors, convulsions, delirium and hallucinations. In severe cases, coma and death can be rapid. Some patients presented with language barriers, slow movements, rigidity, or paralysis, incontinence, etc.
very difficult to diagnose this disease, chronic alcoholism, such as severe clinical manifestations of these patients, the disease should be suspected. However, death rarely diagnosed. autopsy is usually diagnosed after death. A few cases, CT or mri can show the corpus callosum lesions.[Aftertreat]
reasonably small amount of alcohol on the human body may have some benefits, avoid long-term heavy drinking is the prevention of alcoholism Marchliafara-Bignami disease caused by the main measures. The disease is also found in non-alcoholics, cyanide poisoning and carbon monoxide poisoning can also cause this disease, it is important to prevent primary disease.[Treat]
(b) the prognosis
poor prognosis of this disease, very little recovery, severe cases coma and death can be rapid. Some patients can occur within a few years of dementia, and was progressively developed, to the post was completely dementia, strong cry strong laugh, limb stiffness, muscle atrophy, can not walk and was bed-ridden, or even to the cortex status. Eventually died of complications, often after the death of the autopsy before being diagnosed.
progressive degeneration of the corpus callosum, which checks should be done?
4. electromyography and nerve electrophysiology, there is differential diagnosis.[Diff]
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more skin symptoms
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