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Progressive degeneration of the corpus callosum

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[Intro]

Overview: progressive degeneration of the corpus callosum previous literature called Marchliafara-Bignami disease, concurrency is a rare disease in chronic alcoholism. Mostly middle-aged men, often with alcohol, malnutrition and other diseases coexist. disease mainly affects the middle layer of the corpus callosum, followed by the neighboring white matter and small brain, legs may also be involved. No specific treatment for poor prognosis.

[Cause]

progressive degeneration of the corpus callosum is what causes it?

(a) causes

this disease and alcoholism are related, but the disease pathogenesis is unknown. Mainly affects the middle layer of the corpus callosum, followed by the neighboring white matter and small brain, legs may also be involved. Optic radiation and the anterior commissure involvement is rare. Symmetric demyelination lesions. Part or the entire corpus callosum involvement, involvement of the central most important part of the fiber. damage to soft gray area with the naked eye. Microscopic residual glial and vascular lesions and no significant relationship between blood vessels.

(B) the pathogenesis

Marchliafara-Bignami disease pathogenesis is unclear, long-term alcohol abuse is a significant risk factor is undoubtedly , has indeed confirmed that a large number of uncontrolled drinking, many organ systems of the body much harm to both the role of the nervous system is alcohol abuse a major target organ of disease. But the disease is also found in non-alcoholics. Experimental cyanide poisoning and carbon monoxide poisoning can cause the disease, it may be related to ischemia and hypoxia have a relationship.

[Sign]

progressive degeneration of the corpus callosum, the early symptoms?

1. The disease was first proposed by Marchliafara and Bignami (1903) reported. The disease occurs mainly in a variety of alcoholic beverages addiction, severe alcoholism, middle-aged men.

2.Marchliafara-Bignami disease no characteristic clinical manifestations, and other nervous system damage caused by alcoholism are similar, but many patients have cognitive and behavioral abnormalities. Usually anxiety, apathy, hallucinations, mood disorders and abnormal behavior. Patients can occur within a few years for dementia. Some of the performance of periodic stupor and coma, may occur tremors, convulsions, delirium and hallucinations. In severe cases, coma and death can be rapid. Some patients presented with language barriers, slow movements, rigidity, or paralysis, incontinence, etc.

3. signs may have primitive sucking reflex, grasping reflex, and extensor muscle rigidity and so on. In some cases CT or mri can show the narrowing of the corpus callosum and limitations of atrophy.

very difficult to diagnose this disease, chronic alcoholism, such as severe clinical manifestations of these patients, the disease should be suspected. However, death rarely diagnosed. autopsy is usually diagnosed after death. A few cases, CT or mri can show the corpus callosum lesions.

[Aftertreat]

progressive degeneration of the corpus callosum ate?

[Prevent]

progressive degeneration of the corpus callosum should be how to prevent?

reasonably small amount of alcohol on the human body may have some benefits, avoid long-term heavy drinking is the prevention of alcoholism Marchliafara-Bignami disease caused by the main measures. The disease is also found in non-alcoholics, cyanide poisoning and carbon monoxide poisoning can also cause this disease, it is important to prevent primary disease.

[Treat]

progressive degeneration of the corpus callosum precautions before treatment?

(a) treatment

1. first of all to stop drinking alcohol may gradually improve brain function.

2. In addition to aggressive treatment of alcoholism or carbon monoxide poisoning and other primary disease, no specific treatment.

3. symptomatic treatment may be given a variety of vitamins. At the same time should be given to increase brain disease nutrition, improve nerve cell metabolism and other treatment.

(b) the prognosis

poor prognosis of this disease, very little recovery, severe cases coma and death can be rapid. Some patients can occur within a few years of dementia, and was progressively developed, to the post was completely dementia, strong cry strong laugh, limb stiffness, muscle atrophy, can not walk and was bed-ridden, or even to the cortex status. Eventually died of complications, often after the death of the autopsy before being diagnosed.

progressive degeneration of the corpus callosum Chinese medicine treatment methods

No information

progressive degeneration of the corpus callosum western treatment

No information

[Examine]

progressive degeneration of the corpus callosum, which checks should be done?

1. blood and urine alcohol concentration was determined with the diagnosis and assess the significance of the degree of poisoning.

2. Other blood tests including blood chemistry, liver function, renal function, blood coagulation function and immune globulin.

3. ECG, EEG, brain CT or mri examination, differential diagnosis and assess the significance of the degree of poisoning.

4. electromyography and nerve electrophysiology, there is differential diagnosis.

[Diff]

progressive degeneration of the corpus callosum and the diseases easily confused?

1. should pay attention to the disease causing coma phase identification, such as sedative-hypnotics poisoning, carbon monoxide poisoning, stroke, brain trauma.

2. but also with mental illness, epilepsy, asphyxiating gas poisoning, hypoglycemia and other similar identification.

3. mental retardation and personality changes, with other causes of dementia encephalopathy identification.

[Disease]

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more skin symptoms

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